据欧盟食品安全局消息，应欧委会的要求，欧盟食品安全局评估了胭脂树籽皮(annatto)提取物作为食品添加剂的安全性。
胭脂树籽皮提取物分为胭脂树橙(bixin)基与降胭脂树橙(norbixin)基。经过毒理学试验，欧盟食品安全局认为，胭脂树橙的ADI设为6 mg /kg体重/天，降胭脂树橙的ADI设为0.3 mg /kg体重/天较为合理。
部分原文报道如下：
Following a request from the European Commission to EFSA，the EFSA Panel on Food Additives and Nutrient Sources added to Food(ANS)was asked to re-evaluate the safety of annatto extracts，bixin-based and norbixin-based，when used as a food additive and to evaluate the safety of aqueous-processed bixin(Annatto E)；solvent-extracted bixin(Annatto B)；alkali-processed norbixin，acid-precipitated(Annatto F)；alkali-processed norbixin，not acid-precipitated(Annatto G)and solvent-extracted norbixin(Annatto C)with the view to replac the currently authorised annatto extracts(E 160b)。
